https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2948/12880913/e3eb2d74ef49/41593_2025_2131_Fig3_HTML.jpg panel b and e
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2948/12880913/e3eb2d74ef49/41593_2025_2131_Fig3_HTML.jpg
panel b and e