diff --git a/comtypes/client/_events.py b/comtypes/client/_events.py
index e6b662df..603c5531 100644
--- a/comtypes/client/_events.py
+++ b/comtypes/client/_events.py
@@ -120,6 +120,10 @@ def FindOutgoingInterface(source: IUnknown) -> type[IUnknown]:
     except COMError:
         pass
     else:
+        if guid == comtypes.GUID():
+            # Some COM servers, even if they implement `IProvideClassInfo2`,
+            # may return GUID_NULL instead of the default source interface's GUID.
+            raise NotImplementedError("retrieved outgoing interface IID is GUID_NULL")
         # another try: block needed?
         try:
             interface = comtypes.com_interface_registry[str(guid)]
@@ -258,7 +262,15 @@ def _get_method_finder_(self, itf: type[IUnknown]) -> _MethodFinder:
             # Can dispid be at a different index? Should check code generator...
             # ...but hand-written code should also work...
             dispid = m.idlflags[0]
-            assert isinstance(dispid, comtypes.dispid)
+            if not isinstance(dispid, comtypes.dispid):
+                # The interface is a subclass of `IDispatch` but its methods do not
+                # have DISPIDs, indicating it's not an interface suitable for event
+                # handling.
+                raise NotImplementedError(
+                    "Event receiver creation requires event methods to have DISPIDs "
+                    f"for dispatching, but '{interface.__name__}' ({interface._iid_}) "
+                    "lacks them, even though it inherits from 'IDispatch'."
+                )
             impl = finder.get_impl(interface, m.name, m.paramflags, m.idlflags)
             # XXX Wouldn't work for 'propget', 'propput', 'propputref'
             # methods - are they allowed on event interfaces?
diff --git a/comtypes/test/test_eventinterface.py b/comtypes/test/test_eventinterface.py
index d30c0339..9fffc1a9 100644
--- a/comtypes/test/test_eventinterface.py
+++ b/comtypes/test/test_eventinterface.py
@@ -1,8 +1,10 @@
 import gc
+import tempfile
 import time
 import unittest as ut
 from ctypes import HRESULT, byref
 from ctypes.wintypes import MSG
+from pathlib import Path
 
 from comtypes import COMMETHOD, GUID, IUnknown
 from comtypes.automation import DISPID
@@ -111,5 +113,43 @@ def test_nondefault_eventinterface(self):
         del conn
 
 
+class Test_MSHTML(ut.TestCase):
+    def test_retrieved_outgoing_iid_is_guid_null(self):
+        doc = CreateObject("htmlfile")
+        sink = object()
+        # MSHTML's HTMLDocument (which is what `CreateObject('htmlfile')`
+        # returns) does not expose a valid default source interface through
+        # `IProvideClassInfo2`.
+        with self.assertRaises(NotImplementedError):
+            GetEvents(doc, sink)
+
+
+class Test_IMAPI2FS(ut.TestCase):
+    def setUp(self):
+        CLSID_MsftFileSystemImage = GUID("{2C941FC5-975B-59BE-A960-9A2A262853A5}")
+        self.image = CreateObject(CLSID_MsftFileSystemImage)
+        self.image.FileSystemsToCreate = 1  # FsiFileSystemISO9660
+        td = tempfile.TemporaryDirectory()
+        self.tmp_dir = Path(td.name)
+        self.addCleanup(td.cleanup)
+
+    def tearDown(self):
+        del self.image
+        # Force garbage collection and wait slightly to ensure COM resources
+        # are released properly between tests.
+        gc.collect()
+        time.sleep(2)
+
+    def test_event_methods_lack_dispids(self):
+        sink = object()
+        # The default event interface for IMAPI2's FileSystemImage is
+        # `DFileSystemImageEvents`. Although it inherits from `IDispatch`,
+        # it is a custom interface (`TKIND_INTERFACE`), not a dual or pure
+        # dispatch interface (`TKIND_DISPATCH`); therefore, its methods
+        # do not have DISPIDs.
+        with self.assertRaises(NotImplementedError):
+            GetEvents(self.image, sink)
+
+
 if __name__ == "__main__":
     ut.main()