diff --git a/packages/react-native/Libraries/Animated/nodes/AnimatedObject.js b/packages/react-native/Libraries/Animated/nodes/AnimatedObject.js
index afed957d2ab3b1..55df0563892923 100644
--- a/packages/react-native/Libraries/Animated/nodes/AnimatedObject.js
+++ b/packages/react-native/Libraries/Animated/nodes/AnimatedObject.js
@@ -24,11 +24,14 @@ export function isPlainObject(
   /* $FlowFixMe[incompatible-type-guard] - Flow does not know that the prototype
      and ReactElement checks preserve the type refinement of `value`. */
 ): value is $ReadOnly<{[string]: mixed}> {
+  const proto = value !== null && typeof value === 'object' ? Object.getPrototypeOf(value) : undefined;
+  if (proto === undefined) {
+    // $FlowFixMe[incompatible-type-guard]
+    return false;
+  }
   return (
     // $FlowFixMe[incompatible-type-guard]
-    value !== null &&
-    typeof value === 'object' &&
-    Object.getPrototypeOf(value).isPrototypeOf(Object) &&
+    (proto == null || proto.isPrototypeOf(Object)) &&
     !isValidElement(value)
   );
 }