diff --git a/change/@itwin-map-layers-450debab-e24a-42a0-9785-ce0c8157dbe7.json b/change/@itwin-map-layers-450debab-e24a-42a0-9785-ce0c8157dbe7.json
new file mode 100644
index 000000000..39674f3f2
--- /dev/null
+++ b/change/@itwin-map-layers-450debab-e24a-42a0-9785-ce0c8157dbe7.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "Add key prop to Select component for responsive dropdown menu on disabled state change",
+  "packageName": "@itwin/map-layers",
+  "email": "wil.maier@bentley.com",
+  "dependentChangeType": "patch"
+}
diff --git a/packages/itwin/map-layers/src/ui/widget/BasemapPanel.tsx b/packages/itwin/map-layers/src/ui/widget/BasemapPanel.tsx
index 24b24c0f1..4b610aa17 100644
--- a/packages/itwin/map-layers/src/ui/widget/BasemapPanel.tsx
+++ b/packages/itwin/map-layers/src/ui/widget/BasemapPanel.tsx
@@ -408,6 +408,8 @@ export function BasemapPanel(props: BasemapPanelProps) {
           onChange={handleBaseMapSelection}
           size="small"
           disabled={props.disabled}
+          // Use key to reset internal state of Select when disabled changes, ensuring the dropdown menu is responsive.
+          key={String(props.disabled)}
         />
         {baseIsColor && (
           <Popover