Raw RNAseq data is available in the Sequence Read Archive (SRA): https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1243442 Mouse models are available for registering interest at The Jackson Laboratory mouse repository. Summary of ADRD models with JAX registry (JR) stock numbers, mutation details, and phenotyping statuS: JR Strain 3X/4X/5X/6X KI Shorthand Phenotype screening 039995 B6.Cg-Maptem2Lutzy Psen1em1Msasn Appem5Msasn/KmsoJ 3X KI ADRD-3X-1 Yes 035232 B6.Cg-Sncaem2Lutzy Psen1em1Msasn Appem5Msasn/KmsoJ 3X KI ADRD-3X-2 Yes 034021 B6.Cg-Tardbpem9Lutzy Psen1em1Msasn Appem5Msasn/KmsoJ 3X KI ADRD-3X-3 Yes 034542 B6.Cg-Tardbpem9Lutzy Apoetm1.1(APOE4)Adiuj Psen1em1Msasn/KmsoJ 3X KI ADRD-3X-4 No 034543 B6.Cg-Tardbpem9Lutzy Apoetm1.1(APOE4)Adiuj Appem5Msasn/KmsoJ 3X KI ADRD-3X-5 No 034028 C57BL/6J-Tardbpem9Lutzy Sncaem2Lutzy Maptem2Lutzy/KmsoJ 3X KI ADRD-3X-6 No 039996 B6.Cg-Tardbpem9Lutzy Maptem2Lutzy Psen1em1Msasn Appem5Msasn/KmsoJ 4X KI ADRD-4X-1 Yes 034544 B6.Cg-Tardbpem9Lutzy Apoetm1.1(APOE4)Adiuj Psen1em1Msasn Appem5Msasn/KmsoJ 4X KI ADRD-4X-2 Yes 034030 B6.Cg-Tardbpem9Lutzy Sncaem2Lutzy Maptem2Lutzy Psen1em1Msasn/KmsoJ 4X KI ADRD-4X-3 No 034546 B6.Cg-Tardbpem9Lutzy Apoetm1.1(APOE4)Adiuj Maptem2Lutzy Psen1em1Msasn Appem5Msasn/KmsoJ 5X KI ADRD-5X-1 Yes 034029 B6.Cg-Tardbpem9Lutzy Sncaem2Lutzy Maptem2Lutzy Psen1em1Msasn Appem5Msasn/KmsoJ 5X KI ADRD-5X-2 Yes 039997 B6.Cg-Tardbpem9Lutzy Sncaem2Lutzy Apoetm1.1(APOE*4)Adiuj Maptem2Lutzy Psen1em1Msasn Appem5Msasn/KmsoJ 6X KI ADRD-6X-1 No