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@SigProfilerSuite

SigProfilerSuite

Collaboratively maintained by: Alexandrov lab (UCSD, USA), Díaz-Gay lab (CNIO, Spain), Islam lab (UAlbany – SUNY, USA) & Otlu lab (METU, Turkey)

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  1. SigProfilerExtractor SigProfilerExtractor Public

    SigProfilerExtractor allows de novo extraction of mutational signatures from data generated in a matrix format. The tool identifies the number of operative mutational signatures, their activities i…

    Python 176 56

  2. SigProfilerMatrixGenerator SigProfilerMatrixGenerator Public

    SigProfilerMatrixGenerator creates mutational matrices for all types of somatic mutations. It allows downsizing the generated mutations only to parts for the genome (e.g., exome or a custom BED fil…

    Python 117 41

  3. SigProfilerAssignment SigProfilerAssignment Public

    Assignment of known mutational signatures to individual samples and individual somatic mutations

    Python 75 15

  4. SigProfilerPlotting SigProfilerPlotting Public

    SigProfilerPlotting provides a standard tool for displaying all types of mutational signatures as well as all types of mutational patterns in cancer genomes. The tool seamlessly integrates with oth…

    Python 52 16

  5. SigProfilerTopography SigProfilerTopography Public

    SigProfilerTopography allows evaluating the effect of chromatin organization, histone modifications, transcription factor binding, DNA replication, and DNA transcription on the activities of differ…

    Python 24 1

  6. SigProfilerSingleSample SigProfilerSingleSample Public archive

    SigProfilerSingleSample allows attributing a known set of mutational signatures to an individual sample. The tool identifies the activity of each signature in the sample and assigns the probability…

    Python 23 2

Repositories

Showing 10 of 15 repositories
  • SigProfilerAssignment Public

    Assignment of known mutational signatures to individual samples and individual somatic mutations

    SigProfilerSuite/SigProfilerAssignment’s past year of commit activity
    Python 75 BSD-2-Clause 15 1 0 Updated Feb 12, 2026
  • TMB_plotter Public

    Python function for TMB snake plots

    SigProfilerSuite/TMB_plotter’s past year of commit activity
    Python 16 BSD-2-Clause 3 1 0 Updated Feb 12, 2026
  • SigProfilerClusters Public

    Tool for analyzing the inter-mutational distances between SNV-SNV and INDEL-INDEL mutations. Tool separates mutations into clustered and non-clustered groups on a sample-dependent basis.

    SigProfilerSuite/SigProfilerClusters’s past year of commit activity
    Python 14 BSD-2-Clause 3 0 0 Updated Feb 11, 2026
  • SigProfilerSimulator Public

    SigProfilerSimulator allows realistic simulations of mutational patterns and mutational signatures in cancer genomes. The tool can be used to simulate signatures of single point mutations, double point mutations, and insertion/deletions. Further, the tool makes use of SigProfilerMatrixGenerator and SigProfilerPlotting.

    SigProfilerSuite/SigProfilerSimulator’s past year of commit activity
    Python 21 BSD-2-Clause 6 0 0 Updated Feb 10, 2026
  • SigProfilerPlotting Public

    SigProfilerPlotting provides a standard tool for displaying all types of mutational signatures as well as all types of mutational patterns in cancer genomes. The tool seamlessly integrates with other SigProfiler tools.

    SigProfilerSuite/SigProfilerPlotting’s past year of commit activity
    Python 52 BSD-2-Clause 16 1 0 Updated Feb 8, 2026
  • SigProfilerMatrixGenerator Public

    SigProfilerMatrixGenerator creates mutational matrices for all types of somatic mutations. It allows downsizing the generated mutations only to parts for the genome (e.g., exome or a custom BED file). The tool seamlessly integrates with other SigProfiler tools.

    SigProfilerSuite/SigProfilerMatrixGenerator’s past year of commit activity
    Python 117 BSD-2-Clause 41 3 1 Updated Feb 8, 2026
  • SigProfilerExtractor Public

    SigProfilerExtractor allows de novo extraction of mutational signatures from data generated in a matrix format. The tool identifies the number of operative mutational signatures, their activities in each sample, and the probability for each signature to cause a specific mutation type in a cancer sample. The tool makes use of SigProfilerMatrixGen…

    SigProfilerSuite/SigProfilerExtractor’s past year of commit activity
    Python 176 BSD-2-Clause 56 5 1 Updated Feb 1, 2026
  • SigProfilerAssignmentR Public archive

    R wrapper for utilizing the SigProfilerAssignment framework

    SigProfilerSuite/SigProfilerAssignmentR’s past year of commit activity
    R 4 BSD-2-Clause 0 1 0 Updated Jan 29, 2026
  • SigProfilerPlottingR Public archive

    An R wrapper for running the SigProfilerPlotting framework

    SigProfilerSuite/SigProfilerPlottingR’s past year of commit activity
    R 10 BSD-2-Clause 1 1 0 Updated Jan 29, 2026
  • SigProfilerSimulatorR Public archive

    An R wrapper for running the SigProfilerSimulator framework

    SigProfilerSuite/SigProfilerSimulatorR’s past year of commit activity
    R 5 BSD-2-Clause 0 1 0 Updated Jan 29, 2026

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