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Unable to access published Tier 2 FunGen-xQTL Synapse resources (403/404) #38

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@ericzhuang2010

Hello,

I am trying to reproduce candidate-region AD GWAS/xQTL fine-mapping and colocalization analyses using the resources documented in this repository.

I can authenticate successfully to Synapse as user ericzhuang2010, and the ADKP Clickwrap access requirement is approved. However, the following documented entities return HTTP 403 because my account does not have READ permission:

  • syn69670625 — AD GWAS fine-mapping
  • syn69865824 — AD GWAS colocalization models/results
  • syn69865816 — AD–xQTL colocalization results
  • syn69670630 — AD–xQTL colocalization models
  • syn69670592 — xQTL fine-mapping models
  • syn69670632 — raw xQTL summary statistics
  • syn69670652 — ADSP European-ancestry LD matrices

In addition, the documented AD fine-mapping-results entity syn69696846 returns HTTP 404.

The documentation identifies these resources as being under the FunGen-xQTL staging folder (syn68872650). Are these datasets intended to be publicly available, or is additional controlled-access approval or consortium membership required?

Could you please:

  1. Provide the appropriate procedure for requesting READ/DOWNLOAD access;
  2. Grant access to my Synapse account if appropriate; or
  3. Provide the current public Synapse IDs if these staging IDs have been replaced?

Intended use: local, noncommercial research reproducing regional GWAS/xQTL fine-mapping and colocalization comparisons for an Alzheimer’s disease genetic-support analysis.

Thank you.
Eric

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