The Minimum Information about a Molecular Interaction Causal Statement (MI2CAST)
This repository contains the guidelines defined for the curation of causal statements in molecular interactions.
A causal statement is defined as an interaction between biological material entities (gene, protein, etc) where a source entity regulates the activity or the quantity of a target entity.
This repository is a community effort to homogenize and categorize information for representing causal relationships. Terms are defined and ontologies/controlled vocabularies to use are suggested for each term.
Access to the MI2CAST guidelines.
- E2F8 (transcription factor) regulation of CCNE1 (target gene) causal statement,
- Protein kinase A catalytic subunit regulation,
- Two transcription factors regulating a gene.
Vasundra Touré (vasundra.toure@ntnu.no)